The "Saint Dumitru" Church in Orhei is an Orthodox Christian church located in the city of Orhei (Orhei district), Republic of Moldova. Founded by Vasile Lupu, the church was built between 1632 and 1636 and consecrated on the occasion of the ruler's arrival in Orhei in 1637.

The church is part of the National Architectural Heritage, being one of the most important ecclesiastical buildings in the country preserved to this day

The church was founded in 1637 by Vasile Lupu, the ruler of Wallachia between 1634–1653. As a testimony, there is a plaque with the coat of arms of Moldova in the center, installed above the entrance to the church, with the following text:

"With the will of the Father and with the help of the Son and with the accomplishment of the Holy Spirit, this place was founded, in the name of the most glorious God - the miracle worker - Ion Vasile Voievod by the mercy of God, lord of the Country of Moldavia and his Lady Theodosia and the children of the voivode".

A beautiful legend that the old people of Orhei still remember tells us about the beautiful days spent by Prince Vasile Lupu together with his son Ioan on the banks of the Ivanos river. Ioan being very sickly, he often spent time on the banks of the Ivanos, the air and murmur of the clear alley brought benefits to his health. For these reasons, Vasile Lupu built the church of St. Dumitru for the mercy of God and the health of his son

The exterior has been modified over the years, with the addition of a two-tiered bell tower.

The church is of the old mixed Moldavian type. The narthex is rectangular and elongated, the entrance to it is preceded by a closed porch, located not in the continuation of the narthex, but on one side, despite tradition. The bell tower is located above the narthex. The portal is decorated with a stone border in the Gothic style. The windows are also decorated with some Gothic elements. The domes of the nave and narthex are probably the only authentic stone domes in Moldavian churches that have not been affected by the passage of time.

In the churchyard there was a monument to the founder Vasile Lupu. A few years ago it was moved to the city center, near the town hall. The monument is cast in bronze and is the work of sculptor Oscar Han.

In 1939, the church underwent restoration work, an event recorded on a marble plaque placed at the entrance. At the same time, the painter Petru Remus Troteanu restored the murals inside, one of which represents Vasile Lupu holding the model of the church in his hands. Since then, the painting has been visibly affected by candle smoke, but the mural has been well preserved. The bells are riddled with bullet holes, vestiges of World War II.

On October 21, 2016, with the appointment of Archimandrite Siluan (Salari) in the church hierarchy as bishop of Orhei and vicar of the Metropolitanate of Chisinau and all of Moldova, the Church "Saint Dumitru" obtained the status of a cathedral. In this regard, a team of qualified workers, under the coordination of the prot. mitr. Rodion Melnic, the minister of the cathedral, but also with the foundation of the Family of Worthy Christians of Mr. Ion and Viorica Brodețchi from the municipality of Orhei, carried out, in accordance with the recommendations of the Ministry of Education, Culture and Research, several repair and consolidation works of the exterior of the architectural monument, as well as its courtyard, including the restoration of the monument Cross, the roof, and the night lighting of the architectural monument.

On November 8, 2016, on the feast day of the Holy Great Martyr Demetrius the Myrrh-Bearer of Thessaloniki, the spiritual protector of the municipality. Orhei and the Episcopal Cathedral, with the blessing of His Eminence Metropolitan Vladimir, His Eminence Father Siluan (Salari), the newly elected Bishop of Orhei, Vicar of the Metropolitanate of Chisinau and All Moldova, performed the first episcopal service in the premises of the new Episcopal Cathedral.

Alongside His Eminence were the following who co-celebrated on that historic day: His Eminence Ioan Bishop of Soroca, Vicar of the Metropolitanate of Chisinau and All Moldova, Prot. Rodion Melnic, the former parish priest of the cathedral, the Sector Heads of the Orhei Deanery, as well as an imposing council of priests and deacons from the newly established Vicariate of Orhei.

His Holiness Ioan, Bishop of Soroca and Metropolitan Vicar, as a delegate of His Eminence Metropolitan Vladimir, but also as a confrere and good friend of the newly ordained Bishop Siluan of Orhei, presented their new spiritual Shepherd to the priests and faithful that day, wishing His Eminence Siluan sincere and cordial congratulations, that he may continue to be a pillar of hope for the Orthodox Church in Moldova and to wisely shepherd the flock entrusted to him by His Eminence Metropolitan Vladimir. It was a unique moment, a great joy for the entire people, but also for the entire clergy, as the Bishop of the Fortress of Sorocai showed then in his address.